HEMATOPOIESIS AND STEM CELLS Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells
نویسندگان
چکیده
Department of Experimental Hematology and Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Experimental and Clinical Medicine, University of Catanzaro Magna Græcia, Catanzaro, Italy; Biogem Scarl, Institute for Genetic Research Geatano Salvatore, Ariano Irpino, Italy; Laboratory of Molecular Hematopoiesis, University of Catanzaro Magna Græcia, Catanzaro, Italy; and Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre & Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands
منابع مشابه
Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells.
The Polycomb group (PcG) protein BMI1 is a key factor in regulating hematopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the Polycomb repressive complex 1 (PRC1). In humans, each of the 5 subunits of PRC1 has paralog family members of which many reside in PRC1 complexes, likely in a mutually exclusive manner, pointing toward a previously unanticipate...
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Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes. Pcgf5 has been characterized as a component of PRC1.5, one of the non-canonical PRC1, consisting of Ring1a/b, Rybp/Yaf2 and Auts2. However, th...
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